2017-07-05 14:32:582025-04-08 05:32:44
description
anti-SigW
anti-[[protein|SigW]]
locus
BSU01740
BSU_01740
geneLength
624
627
function
control of SigW activity
control of [[protein|SigW]] activity
product
anti-SigW
anti-[[protein|SigW]]
outlinks
bsu
BSU01740
BSU_01740
Gene
Coordinates
195,426 → 196,052
195,426 196,052
The protein
Protein family
anti-sigma-W factor family (according to Swiss-Prot)
zinc-associated anti-sigma factor (ZAS) superfamily (with [[protein|YlaD]], according to UniProt)
anti-sigma-W factor family (single member, according to UniProt)
The protein
[SW|Localization]
membrane (according to Swiss-Prot)
cell membrane (according to UniProt)
Biological materials
Mutant
MGNA-B953 (ybbM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1952 NBRP B. subtilis, Japan]
MGNA-B953 (ybbM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1952 NBRP B. subtilis, Japan]
BKE01740 ([[gene|rsiW]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE01740 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGGACAGCTCATTTCATCAC, downstream forward: _UP4_TAAAGCGCGTTAGCCGCTTT
BKK01740 ([[gene|rsiW]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK01740 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AGGACAGCTCATTTCATCAC, downstream forward: _UP4_TAAAGCGCGTTAGCCGCTTT
Labs working on this gene/protein
[SW|Thomas Wiegert], University of Bayreuth, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/Thomas%20Wiegert-Dateien/Thomas%20Wiegert.html Homepage]
References
Reviews
References
Original Publications
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
The cytoplasmic domain is able to inactivate SigW and the extracellular and transmembrane domains are crucial for sensing and transducing the signal that triggers SigW activation (PubMed:15130127). The N-terminus binds the zinc ion and is followed by a long helix (about residues 40-80) that fits into a hydrophobic surface groove on SigW, probably blocking its ability to interact with the -10 and -35 promoter elements (PubMed:28319136).
labs
[SW|Thomas Wiegert], University of Bayreuth, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/Thomas%20Wiegert-Dateien/Thomas%20Wiegert.html Homepage]